Detalhe da pesquisa
1.
Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation.
N Engl J Med
; 389(8): 710-721, 2023 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37611121
2.
NCI10066: a Phase 1/2 study of olaparib in combination with ramucirumab in previously treated metastatic gastric and gastroesophageal junction adenocarcinoma.
Br J Cancer
; 130(3): 476-482, 2024 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38135713
3.
A Phase I Dose-Escalation Study of LY3405105, a Covalent Inhibitor of Cyclin-Dependent Kinase 7, Administered to Patients With Advanced Solid Tumors.
Oncologist
; 29(1): e131-e140, 2024 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37531083
4.
First-in-human study of oleclumab, a potent, selective anti-CD73 monoclonal antibody, alone or in combination with durvalumab in patients with advanced solid tumors.
Cancer Immunol Immunother
; 72(7): 2443-2458, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37016126
5.
Platinum Sensitivity in IDH1/2 Mutated Intrahepatic Cholangiocarcinoma: Not All "BRCAness" Is Created Equal.
Cancer Invest
; 41(7): 646-655, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37505929
6.
Eftozanermin alfa (ABBV-621) monotherapy in patients with previously treated solid tumors: findings of a phase 1, first-in-human study.
Invest New Drugs
; 40(4): 762-772, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35467243
7.
Evorpacept alone and in combination with pembrolizumab or trastuzumab in patients with advanced solid tumours (ASPEN-01): a first-in-human, open-label, multicentre, phase 1 dose-escalation and dose-expansion study.
Lancet Oncol
; 22(12): 1740-1751, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34793719
8.
A Phase 1 study of RO6870810, a novel bromodomain and extra-terminal protein inhibitor, in patients with NUT carcinoma, other solid tumours, or diffuse large B-cell lymphoma.
Br J Cancer
; 124(4): 744-753, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33311588
9.
Clinical Activity and Safety of Cediranib and Olaparib Combination in Patients with Metastatic Pancreatic Ductal Adenocarcinoma without BRCA Mutation.
Oncologist
; 26(7): e1104-e1109, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33742489
10.
First-in-human evaluation of the novel mitochondrial complex I inhibitor ASP4132 for treatment of cancer.
Invest New Drugs
; 39(5): 1348-1356, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33830407
11.
A phase Ib open-label dose escalation study of the safety, pharmacokinetics, and pharmacodynamics of cobimetinib (GDC-0973) and ipatasertib (GDC-0068) in patients with locally advanced or metastatic solid tumors.
Invest New Drugs
; 39(1): 163-174, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32737717
12.
The effect of sonidegib (LDE225) on the pharmacokinetics of bupropion and warfarin in patients with advanced solid tumours.
Br J Clin Pharmacol
; 87(3): 1291-1302, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32736411
13.
Pre-clinical animal models are poor predictors of human toxicities in phase 1 oncology clinical trials.
Br J Cancer
; 123(10): 1496-1501, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32868897
14.
A Phase Ib Study to Evaluate the MEK Inhibitor Cobimetinib in Combination with the ERK1/2 Inhibitor GDC-0994 in Patients with Advanced Solid Tumors.
Oncologist
; 25(10): 833-e1438, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32311798
15.
Phase Ib Study of Combination Therapy with MEK Inhibitor Binimetinib and Phosphatidylinositol 3-Kinase Inhibitor Buparlisib in Patients with Advanced Solid Tumors with RAS/RAF Alterations.
Oncologist
; 25(1): e160-e169, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31395751
16.
Phase I study of the anti-endothelin B receptor antibody-drug conjugate DEDN6526A in patients with metastatic or unresectable cutaneous, mucosal, or uveal melanoma.
Invest New Drugs
; 38(3): 844-854, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31385109
17.
Phase Ib study of the MEK inhibitor cobimetinib (GDC-0973) in combination with the PI3K inhibitor pictilisib (GDC-0941) in patients with advanced solid tumors.
Invest New Drugs
; 38(2): 419-432, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31020608
18.
First-in-human study of the anti-HB-EGF antibody U3-1565 in subjects with advanced solid tumors.
Invest New Drugs
; 37(1): 147-158, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30056611
19.
Phase I study combining the aurora kinase a inhibitor alisertib with mFOLFOX in gastrointestinal cancer.
Invest New Drugs
; 37(2): 315-322, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30191522
20.
Phase 1 trials of PEGylated recombinant human hyaluronidase PH20 in patients with advanced solid tumours.
Br J Cancer
; 118(2): e3, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29361630